Saturday, 28 September 2013

INTRODUCTION



Welcome to my blog about PGD (Pre-implantation Genetic Diagnosis), a scientific method used to select for or against a certain trait in human embryos.
I believe that PGD is acceptable in order to make sure that your child doesn't suffer from a hereditary disease, however I believe that using it to select traits such as the child's gender, or even such superficial things as hair or eye colour is absolutely inexcusable and should remain illegal.
In this blog I aim to explore the reasons and research behind my standpoint on PGD, and educate others about the negative impacts on society that could be caused if PGD is legal for anything that the parents wish to decide about their baby.
I hope you find my posts informing and that I can persuade you to share my view that PGD is a good thing for determining genetic disorders in embryos, but a bad thing for society when used for other purposes.

HOW PGD WORKS & HEALTH CONSIDERATIONS

Pre-implantation genetic diagnosis is an incredibly complex procedure that many liken to "playing god". I won't go into a lot of detail, if you want the full description you can find out more by clicking here. A simple explanation is that scientists are now able through IVF (In-Vitro Fertilisation) to remove eggs from a woman and mix them with sperm in a laboratory, which will fertilise the eggs and begin the growth of a child. At a very early stage, the scientists are able to remove DNA from each embryo and test it. At present it is only legal in New Zealand to test for genetic disorders such as sickle cell anaemia and chromosome disorders such as Down's Syndrome. However, it is also possible to find out the gender and even hair and eye colour of the baby. After testing, an embryo that is not affected is transferred into the mother's womb. Any other good embryos are frozen in case the pregnancy fails, and unwanted embryos are disposed of.

Unfortunately, due to the complexity of the procedure and the amount of human error that can occur, PGD has no more than a 20% success rate. There is also very little research on the possible effects PGD can have on the child it creates later in life, as it is relatively new technology. There are many potential health risks for the mother too: side effects from the hormones she has to take, a high risk of ectopic pregnancy, higher chance of pregnancy complications, and of course the psychological effects that this trauma to the body, and potentially a miscarriage can cause. Women who want to become mothers through PGD must therefore think very carefully about the risks involved considering that the likelihood that they will be able to fall pregnant is statistically low. In my opinion, this is a woman's own prerogative and not that of the government.




ETHICAL CONSIDERATIONS

I base my viewpoint that PGD should only be used for diagnosis and avoidance of genetic disorders upon many ethical factors. The use of PGD to determine gender and even physical attributes has the potential to spiral downwards and cause a lot of problems further along the line.

PGD is at present incredibly expensive, both in New Zealand and overseas. This means that it is generally only available to very well-off parental candidates, and that in third world countries it's hardly affordable for anyone. While services like this generally decrease in price over time, it is still likely to remain forever out of reach for a vast majority of couples. This logically is likely to increase the rich/poor divide, by allowing the rich to ensure their children aren't disabled and show desired traits, while the poor cannot afford to do so and therefore still have normal children and the regular rate of disability. I personally think that increasing the differences between rich and poor is detrimental to the world. This use of PGD encourages discrimination against non-PGD kids, and that counteracts my belief in the importance of equality.

Another ethical issue that PGD presents is that we have no idea what the consequences may be of drastically altering the world's gene pool. Entire traits may be eradicated, beginning with genetic disorders, but if people are able to choose physical traits such as hair and eye colour, this could lead to other genes being lost forever that could actually be beneficial to human kind and we can't know what negative impacts may come from that. For lack of a better comparison, it's like when dogs were bred to show desired traits and nowadays many pure bred dogs display negative effects of that, such as German Shepherds which are incredibly prone to arthritis, or Corgis which regularly suffer from back problems. We are completely unable to guess what the consequences of widespread PGD may be.




CONCLUSION

PGD is an incredible scientific breakthrough. The first ever baby born by PGD was in 1990, that is just over 20 years ago, and now any couple is able to screen their children for disorders before pregnancy even begins (as long as they can afford it.) The more research that is conducted into genes, then the more traits PGD will be able to select for or against. However just be cause we can, doesn't mean we should. I don't think it's right to take PGD beyond genetic disorders. 

I'm a firm advocate for PGD being used to select against embryos that show up with disorders because if it is going to affect the quality of a child's life and you have another alternative, you should be able to take that alternative. Parents want what's best for their kids and a life that's made incredibly frustrating and difficult by a genetic disorder is not what's best for them.  

However, choosing things that do not affect quality of life such as gender (in first world countries anyway) and physical appearance cannot be justified to me. I simply think it is going to cause a heck of a lot more harm to society than good, in the long run. Humans always want to push the limits of science further and further, but this is one area I think we all need to leave well alone.

REFERENCES

Bonsor, K. & Layton, J. (n.d.). How Designer Children Work. Retrieved September 28, 2013 from http://science.howstuffworks.com/life/genetic/designer-children2.htm

Chen, S. (n.d.). Can Preimplantation Genetic Diagnoses (PGD) Reduce the Risk for Recurrent Pregnancy Loss? Retrieved September 28, 2013 from http://www.inciid.org/printpage.php?cat=pgd&id=265

Genetics & Public Policy Center. (January 2004). Preimplantation Genetic Diagnosis. Retrieved September 28, 2013 from http://www.dnapolicy.org/images/reportpdfs/PGDDiscussionChallengesConcerns.pdf

IVF Traveler. (February 5 2013). SART 2011 US IVF Success Rates for Donor Eggs. Retrieved September 28, 2013 from http://www.ivftraveler.com/blog/sart-2011-us-ivf-success-rates-for-donor-eggs

Sherbahn, R. (n.d.). PGD and IVF Costs - What is the cost for preimplantation genetic diagnosis and/or PGS (preimplantation genetic screening)? Retrieved September 28, 2013 from http://www.advancedfertility.com/pgd-costs.htm


Also,

http://pgdis.org/history.html

http://thetechnologicalcitizen.com/?p=1022

http://www.fertilityassociates.co.nz/information-for-gps/costs.aspx

http://www.propetsciences.com/dog-health/10-breeds-prone-to-dog-arthritis/

http://ownresponsibly.blogspot.co.nz/2011/07/comprehensive-corgi-guide-resource-for.html